PATIENT POPULATION

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Patients with acquired hemophilia A

Patients with acquired hemophilia A are predominantly older, with no personal or family history of bleeding.6

  • Median patient age is ~74 years according to the EACH2 study10
  • Cardiovascular comorbidities are common in the elderly and may create risk of thrombotic complications6

Clinical presentation

Most typical acquired hemophilia A cases present with widespread subcutaneous bleeds.6

Common Types of Bleeding in Acquired Hemophilia A6
Type of Bleed % of Patients
Subcutaneous/skin 81%
Muscle 45%
Gastrointestinal/intra-abdominal 23%
Genitourinary 9%
Retroperitoneal/thoracic 9%
Joint 7%
Example of subcutaneous bleed in acquired hemophilia A

Example of subcutaneous bleed in acquired hemophilia A

Photo courtesy of BioMed Central.

Example of subcutaneous bleed in acquired hemophilia A

Example of subcutaneous bleed in acquired hemophilia A

Photo courtesy of BioMed Central.

Common Types of Bleeding in Acquired Hemophilia A6
Type of Bleed % of Patients
Subcutaneous/skin 81%
Muscle 45%
Gastrointestinal/
intra-abdominal
23%
Genitourinary 9%
Retroperitoneal/thoracic 9%
Joint 7%

Majority of cases are idiopathic (51.9%)6,10

While the majority of acquired hemophilia A cases are idiopathic (51.9%),6,10 there are several underlying disorders that are associated with this condition.*10

These include:

  • All types of malignancies (11.8%)
  • Autoimmune disorders (13.4%)
  • Postpartum (8.4%)
  • Infections (3.8%)
  • Dermatological conditions (1.4%)
  • Drug-induced (3.4%)

*These percentages are from the EACH2 study.