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Doses declined as treatment progressed in the clinical study1

Initial 24 Hours - 200 U/kg

Median Dose
A median of 3 infusions were given

Median Dose: A median of 3 infusions were given

200 U/kg

100 U/kg

0 U/kg

Initial 24 hours1

Beyond 24 hours1

200

U/kg

Median dose

A median of 3 infusions were given

A median of 10.5 infusions were given for a
median of 6 days to control a bleeding episode

Median dose

A median of 3 infusions were given

A median of 10.5 infusions were given for a
median of 6 days to control a bleeding episode

  • The median number of daily infusions per subject was 1.763
  • The median dose per infusion to successfully treat the primary bleeding episode was 133 units per kg and a median total dose of 1523 units per kg1

Median dosing reduction to treat primary bleed5

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  • The median reduction from the initial dose to the subsequent dose was 41.2% in 26 subjects5
  • The median reduction from the initial 24-hour period to subsequent 24-hour periods was 65.4% in 24 subjects5